In this study, efferocytosis, an important link of material and information flow during inflammation, is creatively used to achieve a significant increase of targeted delivery efficiency. A tailored “neutrophil airfreighter” strategy is developed to deliver plenty of siRNA-loaded nanocomplexes (FCM@siNPs) to mtDNA-releasing sentinel mononuclear phagocytes (MPs) in vivo, providing them with immuno-directed information.
