In Chinese symbolism, an elderly person holding a peach and standing on auspicious clouds with a crane, symbolizes luck, wisdom, and longevity. In this issue, Xiao et al. report the transcriptional profiles of peripheral white blood cells from centenarians, centenarian-children, and their spouses and find that autophagy-lysosomal function is significantly enhanced in centenarians. Decreased intracellular accumulation of waste products via enhanced autophagy (shown in the clouds at bottom) may serve as a mechanism to prolong healthy life span.
文章链接：https://genome.cshlp.org/content/28/11.cover-expansion