Skin soft-tissue expansion, a key technique for tissue regeneration, promotes tissue repair by applying sustained mechanical tension. However, prolonged tension leads to the accumulation of apoptotic cells and impaired macrophage efferocytosis, thereby disrupting immune homeostasis and inhibiting regeneration. In this study, an ultrasound-driven electric-conversion hydrogel system (SHG@GBT) is developed, integrating piezoelectric heterojunctions with a reorganized hydrogel network. This system modulates macrophage efferocytosis through ultrasound-generated electrical signals, optimizing the immune microenvironment and promoting regeneration.
