The cover image focuses on neuronal circuit motif with specialized excitatory–inhibitory connectivity pattern. The neuronal circuit is an advanced functional unit of the brain beyond neurons and synapses. Neurons do not function in isolation and are linked to ensembles or circuit motifs that process specific types of information, enables multidimensional signal processing in the information flow of the brain. The authors demonstrate a core processor that can be employed to construct commonly used neuronal circuits and further perform bio-realistic neuromorphic computing. Exploring the working principle, physical configuration, scalable design, and extensive signal-processing capabilities of core processing neuron is crucial for advancing hardware development for brain-inspired integrated neuromorphic systems.